Publications

Research article

Lin A, Mertens AN, Rahman MZ, Tan ST, Il’yasova D, Spasojevic I, Ali S, Stewart CP, Fernald LCH, Kim L, Yan L, Meyer A, Karim MR, Shahriar S, Shuman G, Arnold BF, Hubbard AE, Famida SL, Akther S, Hossen MS, Mutsuddi P, Shoab AK, Shalev I, Rahman M, Unicomb L, Heaney CD, Kariger P, Colford JM Jr, Luby SP, Granger DA. A cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming. Nat Commun. 2024 Apr 26;15(1):3572. PMID: 38670986 Featured in the UC Santa Cruz News.

Nguyen A, Grembi JA, Riviere M, Heitmann GB, Hutson WD, Athni TS, Patil A, Ercumen A, Lin A, Crider Y, Mertens AN, Unicomb L, Rahman M, Colford JM, Luby SP, Arnold BF, Benjamin-Chung J. Influence of temperature and precipitation on the effectiveness of water, sanitation, and handwashing interventions against childhood diarrheal disease in rural Bangladesh: a re-analysis of the WASH Benefits Bangladesh trial. Environ Health Perspect. 2024 Apr;132(4):47006. PMID: 38602833

Butzin-Dozier Z, Mertens AN, Tan ST, Granger DA, Pitchik HO, Il’yasova D, Tofail F, Rahman MZ, Spasojevic I, Shalev I, Ali S, Karim MR, Shahriar S, Famida SL, Shuman G, Shoab AK, Akther S, Hossen MS, Mutsuddi P, Rahman M, Unicomb L, Das KK, Yan L, Meyer A, Stewart CP, Hubbard AE, Naved RT, Parvin K, Mamun MMA, Luby SP, Colford JM, Fernald LCH, Lin A. Stress biomarkers and child development in young children in Bangladesh. Psychoneuroendocrinology. 2024 Mar 11;164:107023. PMID: 38522372

Arnold BF, Rerolle F, Tedijanto C, Njenga SM, Rahman M, Ercumen A, Mertens A, Pickering AJ, Lin A, Arnold CD, Das K, Stewart CP, Null C, Luby SP, Colford JM Jr, Hubbard AE, Benjamin-Chung J. Geographic pair matching in large-scale cluster randomized trials. Nat Commun. 2024 Feb 5;15(1):1069. PMID: 38316755

Jung DK, Tan ST, Hemlock C, Mertens AN, Stewart CP, Rahman MZ, Ali S, Raqib R, Grembi JA, Karim MR, Shahriar S, Roy AK, Abdelrahman S, Shoab AK, Famida SL, Hossen MS, Mutsuddi P, Akther S, Rahman M, Unicomb L, Hester L, Granger DA, Erhardt J, Naved RT, Al Mamun MM, Parvin K, Colford JM Jr, Fernald LCH, Luby SP, Dhabhar FS, Lin A. Micronutrient status during pregnancy is associated with child immune status in rural Bangladesh. Curr Dev Nutr. 2023 Jul 4;7(8):101969. PMID: 37560460

Mertens A, Arnold BF, Benjamin-Chung J, Boehm AB, Brown J, Capone D, Clasen T, Fuhrmeister E, Grembi JA, Holcomb D, Knee J, Kwong LH, Lin A, Luby SP, Nala R, Nelson K, Njenga SM, Null C, Pickerinig AJ, Rahman M, Reese HE, Steinbaum L, Stewart J, Thilakaratne R, Cumming O, Colford JM, Ercumen AE. Effects of water, sanitation, and hygiene interventions on detection of enteropathogens and host-specific faecal markers in the environment: a systematic review and individual participant data meta-analysis. The Lancet Planetary Health 2023; 7(3): e197-e208. PMID: 36889861

Rahman M, Alam MU, Luies SK, Kamal A, Ferdous S, Lin A, Sharior F, Khan R, Rahman Z, Parvez SM, Amin N, Hasan R, Tadesse BT, Taneja N, Islam MA, Ercumen A. Contamination of Fresh Produce with Antibiotic-Resistant Bacteria and Associated Risks to Human Health: A Scoping Review. Int J Environ Res Public Health. 2021 Dec 30;19(1):360. PMID: 35010620

Alam MU, Ferdous S, Ercumen A, Lin A, Kamal A, Luies SK, Sharior F, Khan R, Rahman MZ, Parvez SM, Amin N, Tadesse BT, Moushomi NA, Hasan R, Taneja N, Islam MA, Rahman M. Effective Treatment Strategies for the Removal of Antibiotic-Resistant Bacteria, Antibiotic-Resistance Genes, and Antibiotic Residues in the Effluent From Wastewater Treatment Plants Receiving Municipal, Hospital, and Domestic Wastewater: Protocol for a Systematic Review. JMIR Res Protoc. 2021 Nov 26;10(11):e33365. PMID: 34842550.

Wessells KR, Arnold CD, Stewart CP, Prado EL, Abbeddou S, Adu-Afarwuah S, Arnold BF, Ashorn P, Ashorn U, Becquey E, Brown KH, Byrd KA, Campbell RK, Christian P, Fernald LCH, Fan YM, Galasso E, Hess SY, Huybregts L, Jorgensen JM, Kiprotich M, Kortekangas E, Lartey A, Le Port A, Leroy JL, Lin A, Maleta K, Matias SL, Mbuya MNN, Mridha MK, Mutasa K, Naser AM, Paul RR, Okronipa H, Ouédraogo JB, Pickering AJ, Rahman M, Schulze K, Smith LE, Weber AM, Zongrone A, Dewey KG. Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials. Am J Clin Nutr. 2021 Nov 2;114(Suppl 1):68S-94S. PMID: 34590114

Leder K, Openshaw JJ, Allotey P, Ansariadi A, Barker SF, Burge K, Clasen TF, Chown SL, Duffy GA, Faber PA, Fleming G, Forbes AB, French M, Greening C, Henry R, Higginson E, Johnston DW, Lappan R, Lin A, Luby SP, McCarthy D, O’Toole JE, Ramirez-Lovering D, Reidpath DD, Simpson JA, Sinharoy SS, Sweeney R, Taruc RR, Tela A, Turagabeci AR, Wardani J, Wong T, Brown R. Study design, rationale and methods of the Revitalising Informal Settlements and their Environments (RISE) study: a cluster randomised controlled trial to evaluate environmental and human health impacts of a water-sensitive intervention in informal settlements in Indonesia and Fiji. BMJ Open. 2021 Jan 8;11(1):e042850. PMID: 33419917

French MA, Barker SF, Taruc RR, Ansariadi A, Duffy GA, Saifuddaolah M, Agussalim AZ, Awaluddin F, Zainal Z, Wardani J, Faber PA, Fleming G, Ramsay EE, Henry R, Lin A, O’Toole J, Openshaw J, Sweeney R, Sinharoy SS, Kolotelo P, Jovanovic D, Schang C, Higginson EE, Prescott MF, Burge K, Davis B, Ramirez-Lovering D, Reidpath D, Greening C, Allotey P, Simpson JA, Forbes A, Chown SL, McCarthy D, Johnston D, Wong T, Brown R, Clasen T, Luby SP, Leder K, RISE consortium. A planetary health model for reducing exposure to faecal contamination in urban informal settlements: Baseline findings from Makassar, Indonesia. Environment International. 2021 Oct;155:106679. PMID: 34126296

Benjamin-Chung J, Crider YS, Mertens A, Ercumen A, Pickering AJ, Lin A, Steinbaum L, Swarthout J, Rahman M, Parvez SM, Haque R, Njenga SM, Kihara J, Null C, Luby SP, Colford JM Jr, Arnold BF. Household finished flooring and soil-transmitted helminth and Giardia infections among children in rural Bangladesh and Kenya: a prospective cohort study. Lancet Glob Health. 2021 Mar;9(3):e301-e308. PMID: 33607029

Lappan R, Henry R, Chown SL, Luby SP, Higginson EE, Bata L, Jirapanjawat T, Schang C, Openshaw JJ, O’Toole J, Lin A, Tela A, Turagabeci A, Wong THF, French MA, Brown RR, Leder K, Greening C, McCarthy D. Monitoring of diverse enteric pathogens across environmental and host reservoirs with TaqMan array cards and standard qPCR: a methodological comparison study. Lancet Planet Health. 2021 May;5(5):e297-e308. PMID: 33964239

Lin A, Mertens AN, Arnold BF, Tan S, Lin J, Stewart CP, Hubbard AE, Ali S, Benjamin-Chung J, Shoab AK, Rahman MZ, Famida SL, Hossen MS, Mutsuddi P, Akther S, Rahman M, Unicomb L, Naved RT, Mamun MMA, Parvin K, Dhabhar FS, Kariger P, Fernald LCH, Luby SP, Colford JM. Telomere length is associated with growth in children in rural Bangladesh. eLife. 2021 Sep 8;10:e60389. PMID: 34494545

Leder K, Openshaw JJ, Allotey P, Ansariadi A, Barker SF, Burge K, Clasen TF, Chown SL, Duffy GA, Faber PA, Fleming G, Forbes AB, French M, Greening C, Henry R, Higginson E, Johnston DW, Lappan R, Lin A, Luby SP, McCarthy D, O’Toole JE, Ramirez-Lovering D, Reidpath DD, Simpson JA, Sinharoy SS, Sweeney R, Taruc RR, Tela A, Turagabeci AR, Wardani J, Wong T, Brown R. Protocol: Study design, rationale and methods of the Revitalising Informal Settlements and their Environments (RISE) study: a cluster randomised controlled trial to evaluate environmental and human health impacts of a water-sensitive intervention in informal settlements in Indonesia and Fiji. BMJ Open. 2021 Jan 8;11(1):e042850. PMID: 33419917

Lin A, Mertens AN, Tan S, Rahman, MZ, Hester L, Kim L, Arnold BF, Karim MR, Shahriar S, Ali S, Shoab AK, Hossen MS, Mutsuddi P, Famida SL, Akther S, Rahman M, Unicomb L, Butzin-Dozier Z, Hemlock C, Hubbard AE, Stewart CP,
Fernald LCH, Colford JM, Luby SP, Dhabhar FS. Effects of drinking water, sanitation, handwashing, and nutritional interventions on immune status in young children: a cluster-randomized controlled trial in rural Bangladesh. medRxiv 2021.11.10.21266206; doi: https://doi.org/10.1101/2021.11.10.21266206.

Lin A, Ali S, Arnold BF, Rahman MZ, Alauddin M, Grembi J, Mertens AN, Famida SL, Akther S, Hossen MS, Mutsuddi P, Shoab AK, Hussain Z, Rahman M, Unicomb L, Ashraf S, Naser AM, Parvez SM, Ercumen A, Benjamin-Chung J, Haque R, Ahmed T, Hossain MI, Choudhury N, Jannat K, Alauddin ST, Minchala SG, Cekovic R, Hubbard AE, Stewart CP, Dewey KG, Colford JM, Luby SP. Effects of water, sanitation, handwashing, and nutritional interventions on environmental enteric dysfunction in young children: a cluster-randomized, controlled trial in rural Bangladesh. Clinical Infectious Diseases. 2020 Feb 14;70(5):738-Epub 2019 Apr 9. PMID: 30963177

Grembi JA, Lin A, Karim MA, Islam MO, Miah R, Arnold BF, McQuade ETR, Ali S, Rahman MZ, Hussain Z, Shoab AK, Famida SL, Hossen MS, Mutsuddi P, Rahman M, Unicomb L, Haque R, Taniuchi M, Liu J, Platts-Mills JA, Holmes SP, Stewart CP, Benjamin-Chung J, Colford JM, Houpt ER, Luby SP. Effect of water, sanitation, handwashing and nutrition interventions on enteropathogens in children 14 months old: a cluster-randomized controlled trial in rural Bangladesh. J Infect Dis. 2020 Aug 29; jiaa549. [Online ahead of print] PMID: 32861214

Milner, EM, Kariger P, Pickering AJ, Stewart CP, Byrd K, Lin A, Rao G, Achando B, Dentz HN, Null C, Fernald LCH. Association between Malaria Infection and Early Childhood Development Mediated by Anemia in Rural Kenya. Int J Environ Res Public Health. 2020 Feb;17(3):902. PMID: 32024214

Swarthout J, Ram PK, Arnold CD, Dentz HN, Arnold BF, Kalungu S, Lin A, Njenga SM, Stewart CP, Colford JM, Null C, Pickering AJ. Effects of Individual and Combined Water, Sanitation, Handwashing, and Nutritional Interventions on Child Respiratory Infections in Rural Kenya: A Cluster-Randomized Controlled Trial. Am J Trop Med Hyg. 2020 Jun;102(6):1286-1295. PMID: 32228789

Ercumen A, Benjamin-Chung J, Arnold BF, Lin A, Hubbard AE, Stewart CP, Rahman Z, Parvez SM, Unicomb L, Rahman M, Haque R, Colford JM, Luby SP. Effects of water, sanitation, handwashing and nutritional interventions on soil-transmitted helminth infections in young children: a cluster-randomized controlled trial in rural Bangladesh. PLoS Negl Trop Dis. 2019 May 3;13(5):e0007323. PMID: 31050672

Pickering AJ, Njenga S, Steinbaum L, Swarthout J, Lin A, Arnold BF, Stewart CP, Dentz HN, Mureithi M, Chieng B, Wolfe M, Mahoney R, Kihara J, Byrd K, Rao G, Meerkerk T, Cheruiyot P, Papaiakovou M, Pilotte N, Williams SA, Colford JM, Null C. Effects of single and integrated water, sanitation, handwashing, and nutrition interventions on child soil-transmitted helminth and Giardia infections: a cluster-randomized controlled trial in rural Kenya. PLoS Med. 2019 Jun;16(6):e1002841. PMID: 31242190

Stewart CP, Dewey KG, Lin A, Pickering AJ, Byrd KA, Jannat K, Ali S, Rao G, Dentz HN, Kiprotich M, Arnold CD, Allen LH, Shahab-Ferdows S, Ercumen A, Grembi JA, Naser AM, Rahman M, Unicomb L, Colford JM, Luby SP, Null C. Effects of lipid-based nutrient supplements and infant and young child feeding counseling with or without improved water, sanitation, and hygiene (WASH) on anemia and micronutrient status: results from 2 cluster-randomized trials in Kenya and Bangladesh . Am J Clin Nutr. 2019 Jan 1;109(1):148-164. PMID: 30624600

Pickering AJ, Swarthout J, Mureithi M, Mboya J, Arnold BF, Wolfe M, Dentz HN, Lin A, Arnold CD, Rao G, Stewart CP, Ram PK, Clasen T, Colford JM, Null C. Can individual and integrated water, sanitation, and handwashing interventions reduce fecal contamination in the household environment? Evidence from the WASH Benefits cluster. bioRxiv 731992; doi: https://doi.org/10.1101/731992

Taruc RR, Saifuddaolah M, Agussalim AZ, Wardani J, Sirajuddin S, Barker SF, Duffy GA, Faber PA, Fleming GM, Henry R, Jovanovic D, Lin A, O’Toole J, Openshaw JJ, Sweeney R, Allotey P, Cahan B, Forbes A, Greening C, McCarthy DT, Simpson JA, Chown SL, Johnston DW, Luby SP, Reidpath D, French M, Leder KS, Ramirez-Lovering D, Wong T, Brown RR. Implementing baseline ecological and human health field assessments in the Revitalizing Informal Settlements and their Environments (RISE) programme in Makassar, Indonesia: an interdisciplinary study. Lancet Planet Health. 2019 Sept; DOI: https://doi.org/10.1016/S2542-5196(19)30151-2

Luby SP, Rahman M, Arnold BF, Unicomb L, Ashraf S, Winch PJ, Stewart CP, Begum F, Hussain F, Benjamin-Chung J, Leontsini E, Naser AM, Parvez SM, Hubbard AE, Lin A, Nizame FA, Jannat K, Ercumen A, Ram PK, Das KK, Abedin J, Clasen TF, Dewey KG, Fernald LCH, Null C, Ahmed T, Colford JM. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Bangladesh: a cluster randomised controlled trial. Lancet Glob Health. 2018 Mar;6(3):e302-e315. Epub 2018 Jan 29. PMID: 29396217

Null C, Stewart CP, Pickering AJ, Dentz HN, Arnold BF, Arnold CD, Benjamin-Chung J,Clasen T, Dewey KG, Fernald LCH, Kariger P, Lin A, Luby SP, Mertens A, Njenga SM,Nyambane G, Ram PK, Colford JM. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya: a cluster-randomised controlled trial. Lancet Glob Health. 2018 Mar;6(3):e316-e329. Epub 2018 Jan 29. PMID: 29396219

Stewart CP, Kariger P, Fernald LCH, Pickering AJ, Arnold CD, Arnold BF, Hubbard AE,Dentz HN, Lin A, Meerkerk TJ, Colford JM, Null C Effects of water quality, sanitation, handwashing, and nutritional interventions on child development: a cluster-randomised controlled trial in rural Kenya. Lancet Child Adolesc Health. 2018 Apr;2(4):269-280. PMID: 29616236

Lin A, Ercumen A, Benjamin-Chung J, Arnold BF, Das S, Haque R, Ashraf S, Parvez SM, Unicomb L, Rahman M, Hubbard AE, Stewart CP, Colford JM, Luby SP. Effects of water, sanitation, handwashing, and nutritional interventions on protozoan infections in young children: a cluster-randomized controlled trial in rural Bangladesh. Clinical Infectious Diseases. 2018 Oct 30;67(10):1515-1522. Epub 2018 Apr 13. PMID: 29669039.

Vaz Nery S, Bennett I, Clarke NE, Lin A, Rahman Z, Rahman M, Clements ACA. Characterisation of environmental enteropathy biomarkers and associated risk factors in children in the context of a WASH trial in Timor-Leste. Intl J Hyg Environ Health 2018 Jul;221(6):901-906. Epub 2018 Jun 8. PMID: 29891218

Byrd KA, Williams TN, Lin A, Pickering AJ, Arnold BF, Arnold CD, Kiprotich M, Dentz HN, Njenga SM, Rao G, Colford JM, Null C, Stewart CP. Sickle Cell and α⁺-Thalassemia Traits Influence the Association between Ferritin and Hepcidin in Rural Kenyan Children Aged 14–26 Months. J Nutr. 2018 Dec 1;148(12):1903-1910. PMID: 30517728

Williams AM, Stewart CP, Shahab-Ferdows S, Hampel D, Kiprotich M, Achando B, Lin A, Null C, Allen LH, Chantry CJ. Infant serum and maternal milk vitamin B-12 are positively correlated in Kenyan infant-mother dyads at 1–6 months postpartum, irrespective of infant feeding practice. J Nutr 2018 Jan 1;148(1):86-93. PMID: 29378045

Lin A, Arnold BF, Mertens AN, Lin J, Benjamin-Chung J, Ali S, Hubbard AE, Stewart CP, Shoab AK, Rahman MZ, Hossen MS, Mutsuddi P, Famida SL, Akther S, Rahman M, Unicomb L, Dhabhar FS, Fernald LCH, Colford JM, Luby SP. Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh. eLife. 2017 Oct; 6. PMCID: PMC5675593. Featured on the frontpage of eLife and the cover of The Scientist.

Williams AM, Chantry CJ, Young SL, Achando BS, Allen LH, Arnold BF, Colford JM, Dentz HN, Hampel D, Kiprotich MC,
Lin A, Null CA, Nyambane GM, Shahab-Ferdows S, Stewart CP. Vitamin B-12 concentrations in breast milk are low and are not associated with reported household hunger, recent animal-source food, or vitamin B-12 intake in women in rural Kenya. J Nutr. 2016 May;146(5):1125-31. PMCID: PMC4841927

Arnold BF, Null C, Luby SP, Unicomb L, Stewart CP, Dewey KG, Ahmed T, Ashraf S,Christensen G, Clasen T, Dentz HN, Fernald LC, Haque R, Hubbard AE, Kariger P, Leontsini E, Lin A, Njenga SM, Pickering AJ, Ram PK, Tofail F, Winch PJ, Colford JM Jr. Cluster-randomised controlled trials of individual and combined water, sanitation, hygiene and nutritional interventions in rural Bangladesh and Kenya: the WASH Benefits study design and rationale. BMJ Open. 2013 Aug 30;3(8):e003476. PMCID: PMC3758977

Lin A, Arnold BF, Afreen S, Goto R, Huda T, Haque R, Raqib R, Unicomb L, Ahmed T, Colford JM, Luby SP. Household environmental conditions are associated with enteropathy and impaired growth in rural Bangladesh. Am J Trop Med Hyg. 2013 Jul;89(1):130-7. Cited 440 times.

Lin A, Bik EM, Costello EK, Dethlefsen L, Haque R, Relman DA, Singh U. Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States. PLoS One. 2013 Jan;8(1):e53838. Cited 357 times.